Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure
D. Lang, H. Ni, R. Medvedev, F. V. Liu, C. P. Alvarez-Baron, L. Tyan, D. Turner, A. Warden, S. Morotti, T. Schrauth, B. Chanda, T. J. Kamp, G. Robertson, E. Grandi, A. V. Glukhov
This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.
bioRxiv · Apr 14, 2024 · PreprintPhysiology