F. Salerno

Zfp36l1 establishes the high affinity CD8 T cell response by directly linking TCR affinity to cytokine sensing

The paper shows ZFP36L1 links TCR affinity to cytokine sensing, promoting clonal expansion of high affinity CD8 T cells through IL2 competition.

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

The paper integrates proteome and transcriptome data from mouse B cells to identify poised mRNAs and translational regulators involved in activation and antibody secretion.

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.

The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition.

The paper identifies YTHDF2 as an m6A binding protein that promotes B cell to plasma cell transition in vitro and in chimeric mice.

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

This study identifies ZFP36 and ZFP36L1 as RNA binding proteins that regulate the timing and potency of CD8+ T cell differentiation and effector function during immune response.

Costimulation through TLR2 drives polyfunctional CD8+ T cell responses

This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

The paper shows that post-transcriptional regulation, specifically mRNA stability, limits IFN-γ production in tumor-infiltrating T cells, and restoring this stability enhances anti-tumor effects.

Computational assessment of blood flow heterogeneity in dialysis patients’ cardiac ventricles

The paper uses a biophysical model to analyze blood flow heterogeneity in dialysis patients' hearts, finding that vascular blockages and pressure changes affect flow patterns and heterogeneity.