Author

M. Secrier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:imaging· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. J. Wiecek· 3 shared G. Malagoli Tagliazucchi· 3 shared A. R. Barr· 2 shared D. H. Jacobson· 2 shared E. Withnell· 2 shared M. Parreno-Centeno· 2 shared S. J. Cutty· 2 shared S. Pan· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

A. J. Wiecek

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pro-survival roles for p21(Cip1/Waf1) in Non-Small Cell Lung Cancer

S. J. Cutty, F. A. Hughes, P. Ortega-Prieto, S. Desai, P. Thomas, L. V. Fets, M. Secrier, A. R. Barr

This study shows that p21Cip1/Waf1 promotes survival and relapse in TP53 wild-type NSCLC by enabling quiescence and protecting cells from chemotherapy.

bioRxiv · May 21, 2024Cancer Biology

HistoMIL: a Python package for training Multiple Instance Learning models on histopathology slides

S. Pan, M. Secrier

HistoMIL simplifies training Multiple Instance Learning models on histopathology slides, achieving up to 85% AUROC for cancer gene prediction.

bioRxiv · Jun 2, 2023Pathology

A deep learning and graph-based approach to characterise the immunological landscape and spatial architecture of colon cancer tissue

M. Parreno-Centeno, G. Malagoli Tagliazucchi, E. Withnell, S. Pan, M. Secrier

This paper develops a deep learning and graph-based method to analyze colon cancer tissue, identifying immune patterns and structural biomarkers from H&E slides.

bioRxiv · Jul 6, 2022 · PreprintCancer Biology

Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer

A. J. Wiecek, S. J. Cutty, D. Kornai, M. Parreno-Centeno, L. E. Gourmet, G. Malagoli Tagliazucchi, D. H. Jacobson, P. Zhang, L. Xiong, G. L. Bond, A. R. Barr, M. Secrier

This study identifies genomic features of G0 cell cycle arrest in cancer and links it to therapy resistance using transcriptomic analysis and machine learning.

bioRxiv · Nov 12, 2021 · PreprintCancer Biology

Genomic and local microenvironment effects shaping epithelial-to-mesenchymal trajectories in cancer

G. Malagoli Tagliazucchi, A. J. Wiecek, E. Withnell, M. Secrier

The paper identifies three EMT macro-states in cancer tumors and shows their association with genomic features and microenvironment interactions.

bioRxiv · Jul 23, 2021 · PreprintCancer Biology

Pan-cancer survey of tumour mass dormancy and underlying mutational processes

A. J. Wiecek, D. H. Jacobson, W. Lason, M. Secrier

This study identifies immunological and angiogenic dormancy signals in 16.5% of cancers, links them to specific mutations and environmental factors, and associates dormancy with improved patient survival.

bioRxiv · Apr 25, 2021Cancer Biology