S. Pan

Proposal of two new genera and seventy-seven new species of ascomycetous yeasts isolated from China

The paper describes 77 new ascomycetous yeast species and proposes two new genera based on phylogenetic analysis of rDNA sequences from Chinese isolates.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Protein SUMOylation promotes cAMP-independent EPAC1 activation

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

HistoMIL: a Python package for training Multiple Instance Learning models on histopathology slides

HistoMIL simplifies training Multiple Instance Learning models on histopathology slides, achieving up to 85% AUROC for cancer gene prediction.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector

This study identifies how the tomato yellow leaf curl virus uses a host-mimicking protein domain to disrupt plant processes and attract insect vectors, facilitating viral spread.

Mapping global land sharing-sparing patterns between human and wildlife

The paper maps global land sharing-sparing patterns between humans and wildlife using human-nature indices and classifies lands into four categories based on biodiversity and human pressure.

In vivo and In vitro Characterization of the ClpC AAA+ ATPase of Chlamydia trachomatis

This study characterizes the ClpC AAA+ ATPase of Chlamydia trachomatis using in vitro and in vivo approaches, revealing its essential role in chlamydial growth and identifying it as a potential target for anti-chlamydial agents.

A deep learning and graph-based approach to characterise the immunological landscape and spatial architecture of colon cancer tissue

This paper develops a deep learning and graph-based method to analyze colon cancer tissue, identifying immune patterns and structural biomarkers from H&E slides.

Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

Accelerated Bone Healing in Calvarial and Femoral Defects with Injectable Microcarriers that Mimic the Osteogenic Niche

This study shows that injectable OCM-GelMA microcarriers enhance bone healing in mouse models, comparable to BMP-2, by promoting osteogenic and angiogenic cytokine secretion from OEhMSCs.

Clinical Strains of Pseudomonas aeruginosa secret LasB protease to induce hemorrhagic diffused alveolar damage and acute lung injury in mice

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.

Pseudomonas aeruginosa induced acute emphysema through bacterial secretion in mice

This study shows that Pseudomonas aeruginosa secretion causes acute emphysema in mice, which requires immune suppression and recapitulates human COPD features.

Plant DNA polymerases alpha and delta mediate replication of geminiviruses

This study identifies DNA polymerases alpha and delta as key mediators of geminivirus replication in plants, with C3 protein selectively recruiting polymerase delta for efficient viral genome synthesis.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

High affinity of Skp to OmpC revealed by single-molecule detection

This study uses single-molecule detection to show Skp binds OmpC with high affinity, revealing stoichiometry modulation in the complex formation.

Menthol in Electronic Cigarettes: A Contributor to Respiratory Disease?

This study investigates how menthol in e-cigarettes affects human bronchial epithelium using three in vitro models, finding adverse effects including oxidative stress and inflammation.

The COMPASS-like complex modulates fungal development and pathogenesis by regulating H3K4me3-mediated targeted gene expression in Magnaporthe oryzae

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

Genome-wide analysis of MIKC-type MADS-box genes in wheat: pervasive duplications may have facilitated adaptation to different environmental conditions

The paper analyzes MIKC-type MADS-box genes in wheat, finding their expansion and functional diversity may aid adaptation to environmental conditions.

Glycosylation of gigaxonin regulates intermediate filaments: Novel molecular insights into giant axonal neuropathy

This study identifies O-GlcNAcylation of gigaxonin as a regulatory mechanism linking metabolism to intermediate filament proteostasis, offering insights into giant axonal neuropathy.

The synchronization and adaptation of Neurospora crassa circadian and conidiation rhythms to short light-dark cycles

This study investigates how Neurospora crassa adapts its circadian and conidiation rhythms to short light-dark cycles, showing that core clock protein FREQUENCY entrains to cycles longer than 3:3 but free runs otherwise.

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

This study shows that autophagy reduces lung injury by inhibiting the NF-κB pathway and inflammatory mediator release in hypoxia models.