Author

M. Semproni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Franchitto· 3 shared P. Pichierri· 3 shared E. Malacaria· 2 shared P. Valenzisi· 2 shared V. Palermo· 2 shared A. Noto· 1 shared A. Palma· 1 shared A. Pellicioli· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

A. Franchitto

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

V. Palermo, E. Malacaria, M. Semproni, B. Perdichizzi, P. Valenzisi, M. Sanchez, F. Marini, A. Pellicioli, A. Franchitto, P. Pichierri

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

bioRxiv · Feb 11, 2024Cell Biology

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

A. Noto, P. Valenzisi, F. Fratini, T. Kulikowicz, J. A. Sommers, F. Di Feo, V. Palermo, M. Semproni, M. Crescenzi, R. M. Brosh, A. Franchitto, P. Pichierri

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

E. Malacaria, C. Figlioli, A. Palma, S. Rinalducci, M. Semproni, A. Franchitto, P. Pichierri

This study identifies CHK2's role in regulating MUS81-dependent DSBs during replication stress and BRCA2 deficiency by phosphorylating MUS81.

bioRxiv · Oct 8, 2022Cell Biology