Author

M. Sleutel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Pradhan· 3 shared H. Remaut· 3 shared A. E. S. Van Driessche· 1 shared A.-K. Llarena· 1 shared C. Martens· 1 shared E. D. Zegeye· 1 shared F. Sobott· 1 shared G. Schoehn· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

B. Pradhan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A novel class of ultra-stable endospore appendages decorated with collagen-like tip fibrillae

H. Remaut, M. Sleutel, E. D. Zegeye, A.-K. Llarena, B. Pradhan, M. Fislage, K. O'Sullivan, M. E. Aspholm

The paper identifies a novel class of ultra-stable endospore appendages in Bacillus paranthracis, revealing their structure, genetic basis, and phylogenetic distribution.

bioRxiv · Oct 23, 2023 · PreprintMicrobiology

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid production

J. K. Claridge, C. Martens, B. Pradhan, F. Sobott, M. Sleutel, H. Remaut

This study investigates the molecular mechanism of curli amyloid formation in Salmonella and Escherichia coli, revealing a folding-limited nucleation process that balances efficient polymerization with avoiding premature aggregation.

bioRxiv · May 26, 2023 · PreprintBiochemistry

Structural analysis of the bacterial amyloid curli

M. Sleutel, B. Pradhan, H. Remaut

The paper presents an atomic model of bacterial curli protofibrils using AlphaFold2 and cryo-EM, revealing structural diversity and explaining their robustness and inter-species promiscuity.

bioRxiv · Feb 28, 2022 · PreprintBiochemistry

Nonclassical nucleation of protein mesocrystals via oriented attachment

A. E. S. Van Driessche, N. Van Gerven, R. R. M. Joosten, W. L. Ling, M. Bacia, G. Schoehn, N. A. J. M. Sommerdijk, M. Sleutel

The paper observes oriented attachment in protein crystallization, challenging previous classifications and showing non-classical nucleation mechanisms.

bioRxiv · Aug 27, 2020Biochemistry