B. Pradhan

A novel class of ultra-stable endospore appendages decorated with collagen-like tip fibrillae

The paper identifies a novel class of ultra-stable endospore appendages in Bacillus paranthracis, revealing their structure, genetic basis, and phylogenetic distribution.

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid production

This study investigates the molecular mechanism of curli amyloid formation in Salmonella and Escherichia coli, revealing a folding-limited nucleation process that balances efficient polymerization with avoiding premature aggregation.

L1 retrotransposition is regulated post-transcriptionally In High-Grade Serous Ovarian Cancer

The paper investigates L1 retrotransposition in HGSC, finding that despite high L1 mRNA expression, only a third of tumors show somatic insertions, with variability in retrotransposition frequency and patterns.

Can pseudotopological models for SMC-driven DNA loop extrusion explain the traversal of physical roadblocks bigger than the SMC ring size?

This study evaluates pseudotopological models of SMC-driven DNA loop extrusion and finds they conflict with experimental data on roadblock traversal.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

The Smc5/6 complex is a DNA loop extruding motor

The paper identifies Smc5/6 as a DNA-loop-extruding motor, showing it extrudes loops via dimerization and ATP hydrolysis at 1 kb/s.

Structural analysis of the bacterial amyloid curli

The paper presents an atomic model of bacterial curli protofibrils using AlphaFold2 and cryo-EM, revealing structural diversity and explaining their robustness and inter-species promiscuity.

ParS-independent recruitment of the bacterial chromosome-partitioning protein ParB

This study shows ParB can recruit itself to DNA independently of parS, enabling long-distance chromosome segregation in bacteria.

SMC complexes can traverse physical roadblocks bigger than their ring size

The paper shows that SMC complexes can extrude DNA loops around large DNA-bound obstacles, suggesting a nontopological mechanism for loop extrusion.

Condensin-driven loop extrusion on supercoiled DNA

This study investigates how condensin-driven DNA loop extrusion is influenced by supercoiling using single-molecule imaging and atomic force microscopy.

Bacillus endospore appendages form a novel family of disulfide-linked pili

The paper identifies and characterizes endospore appendages (Enas) in Bacillus cereus, revealing their structure and adaptation to harsh environmental conditions.