Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies
C. Galicia, G. Guaitoli, M. Fislage, C. J. Gloeckner, W. Versees
This paper solves the structure of a bacterial Roco protein in its GTP-bound state using cryo-EM and nanobodies, revealing conformational changes and allosteric activation mechanisms.
bioRxiv · Nov 13, 2023 · PreprintBiochemistry