M. Smerlak

The paper derives improved analytical estimates for the mean click time of Muller's ratchet using a modified diffusion equation.

The paper introduces genotypic reproductive value as a framework to predict evolutionary trajectories in quasi-species dynamics, showing it outperforms traditional fitness and flatness measures.

The paper provides theoretical evidence that viral genome fragility evolves due to population bottlenecks, showing it can increase survival through bottlenecks and attack rates in certain conditions.

The paper shows that clonal interference of neutral variants limits evolvability by restricting access to neutral ridges, and connects evolutionary dynamics to a maximal-entropy random walk.

This paper introduces a generalized quasispecies theory to predict evolutionary trajectories by identifying metastable states as minima of an effective potential, applicable across mutation rates.

The paper quantifies how scaffold evolutionary maturation affects antibody library response to selection, finding maturated scaffolds show lower response to arbitrary targets.