Author

M. Sprang

University Medical Center of the Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Chen· 1 shared A. Gabele· 1 shared A. Meinhardt· 1 shared B. Wasser· 1 shared Christiane PleugeriD· 1 shared D. Ai· 1 shared D. Gomez-Zepeda· 1 shared G. Harms· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Chen

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2 papers

Recent·Most cited

Depletion of CX3CR1+ macrophages results in disrupted functionality and immune surveillance within epididymis and testis

D. Ai, Linda Kreyling, María Agustina Battistone, Maia Lina Elizagaray, A. Chen, S. Bhushan, Monika Fijak, Martin Speckmann, G. Michel, Tara Procida‐Kowalski, Marek Bartkuhn, M. Sprang, Johannes U. Mayer, A. Meinhardt, Christiane Pleuger

This study shows that CX3CR1+ macrophages are essential for maintaining immune balance and epithelial integrity in the epididymis and testis, with their depletion leading to immune dysfunction and fertility issues.

Mucosal Immunology · Jan 31, 2026Peer-reviewedImmunology

Unveiling IRF4-steered regulation of context-dependent effector programs in Th17 and Treg cells

A. Gabele, M. Sprang, M. Cihan, S. Dietzen, M. Klein, G. Harms, T. Ziesmann, K. Pape, B. Wasser, D. Gomez-Zepeda, K. Braband, M. Delacher, N. Lemmermann, S. Bittner, M. A. Andrade-Navarro, , U. Distler

This study identifies IRF4 interactors and their role in regulating context-dependent transcriptional programs in Th17 and Treg cells using ChIP-Seq and proteomics.

bioRxiv · Sep 14, 2023 · PreprintImmunology