CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization
M. Pein, J. Insua-Rodriguez, J. Meier, T. Hongu, L. Wiedmann, M. A. G. Essers, H.-P. Sinn, S. Spaich, M. Sutterlin, A. Schneeweiss, A. Trumpp, T. Oskarsson
This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.
bioRxiv · Feb 11, 2019Cancer Biology