Author

S. Spaich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Trumpp· 3 shared A. Schneeweiss· 2 shared M. Suetterlin· 2 shared C. Conrad· 1 shared C. H. Scheel· 1 shared C. Klein· 1 shared E. Donato· 1 shared E. Espinet· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

A. Trumpp

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Author profile →

3 papers

Recent·Most cited

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

L. Eichelberger, M. Saini, H. D. Moreno, C. Klein, J. M. Bartsch, M. Falcone, M. Reitberger, E. Espinet, V. Vogel, E. Graf, T. Schwarzmayr, T.-M. Strom, M. Lehmann, M. Koenigshoff, N. Pfarr, , C. H. Scheel

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

M. Pein, J. Insua-Rodriguez, J. Meier, T. Hongu, L. Wiedmann, M. A. G. Essers, H.-P. Sinn, S. Spaich, M. Sutterlin, A. Schneeweiss, A. Trumpp, T. Oskarsson

This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.

bioRxiv · Feb 11, 2019Cancer Biology

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

J. Neugebauer, F. M. Zickgraf, J. Park, S. Wagner, X. Jiang, K. Jechow, K. Kleinheinz, U. H. Toprak, M. A. Schneider, M. Meister, S. Spaich, M. Suetterlin, M. Schlesner, A. Trumpp, M. Sprick, , C. Conrad

The paper compares drug responses in ovarian cancer organoids and monolayer cultures, finding differences in drug efficacy and genomic associations.

bioRxiv · Apr 6, 2017Cancer Biology