T. Oskarsson

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

The paper identifies four secreted factors from metastasis-associated endothelial cells that promote breast cancer metastasis by enhancing cancer cell stemness and survival, with perivascular macrophages mediating this effect via the TNC-TLR4 axis.

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.

Tumor pre-conditioning of draining lymph node stroma by lactic acid

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.