Antibiotic concentrations in the sinonasal secretions and tissue in CRS patients after oral therapy: a randomized trial
J. Siu, L. Klingler, Y. Wang, C.-T. Hung, S. H. Jeong, S. Smith, M. Tingle, B. Mackenzie, K. Biswas, R. G. Douglas
This study measures antibiotic concentrations in sinonasal secretions, tissues, and serum after oral therapy in CRS patients, finding lower mucosal penetration and no significant clinical benefit except for slightly higher GSRS scores in the roxithromycin group.
bioRxiv · Jun 17, 2020 · PreprintPharmacology & Toxicology