K. Biswas

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

Development of a high-throughput barrier function assay using primary human gut organoids

The paper develops a high-throughput assay using primary human gut organoids to assess barrier function and response to TNF-α, showing dose-dependent rescue by antagonists.

PKM2-mediated epigenetic reprogramming regulates hypoxic expression of PFKFB3 to promote breast cancer progression

This study identifies PKM2's role in hypoxic breast cancer by regulating PFKFB3 expression through epigenetic reprogramming and HIF-1/HIF-2 interactions.

Universality of phenotypic distributions in bacteria

The paper identifies universal phenotypic distributions in bacteria by analyzing single-cell data and shows that shape-factors explain the universality of certain traits.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT)

This study identifies SLUG as a stabilizer of hybrid epithelial/mesenchymal phenotypes through computational systems biology analysis.

Antibiotic concentrations in the sinonasal secretions and tissue in CRS patients after oral therapy: a randomized trial

This study measures antibiotic concentrations in sinonasal secretions, tissues, and serum after oral therapy in CRS patients, finding lower mucosal penetration and no significant clinical benefit except for slightly higher GSRS scores in the roxithromycin group.

NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype

This study identifies NFATc as a non-canonical phenotypic stability factor that stabilizes hybrid epithelial/mesenchymal phenotypes by enabling coexistence and transitions between epithelial, mesenchymal, and hybrid states.

Comparison of subtyping approaches and the underlying drivers of microbial signatures for chronic rhinosinusitis

This paper compares microbial subtyping approaches in CRS patients, finding that Dirichlet clustering provides better resolution of tight junction impairment than clinical phenotyping.