Author

B. MacKenzie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. Coelho· 2 shared B. Creyns· 2 shared C. M. Hogaboam· 2 shared A. Guenther· 1 shared B. Windsor· 1 shared C. Ruppert· 1 shared C.-T. Hung· 1 shared D. Christensen· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. L. Coelho

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis

B. MacKenzie, P. Mahavadi, Y. A. P. Jannini-Sa, B. Creyns, A. L. Coelho, M. Espindola, C. Ruppert, K. Hoetzenecker, C. M. Hogaboam, A. Guenther

This study evaluates the anti-fibrotic effects of LTI-03 in IPF patient-derived precision cut lung slices, showing dose-dependent reduction of fibrotic markers.

bioRxiv · Apr 24, 2024 · PreprintPharmacology & Toxicology

Caveolin scaffolding domain (CSD) peptide LTI-2355 modulates the phagocytic and synthetic activity of lung derived myeloid cells in Idiopathic Pulmonary Fibrosis (IPF) and Post-acute sequelae of COVID-fibrosis (PASC-F)

B. Creyns, B. MacKenzie, Y. Sa, A. L. Coelho, D. Christensen, T. Parimon, B. Windsor, C. M. Hogaboam

This study shows that the CSD peptide LTI-2355 improves phagocytic and reduces pro-inflammatory activity in myeloid cells from IPF and PASC-F patients.

bioRxiv · Dec 1, 2023Immunology

Antibiotic concentrations in the sinonasal secretions and tissue in CRS patients after oral therapy: a randomized trial

J. Siu, L. Klingler, Y. Wang, C.-T. Hung, S. H. Jeong, S. Smith, M. Tingle, B. Mackenzie, K. Biswas, R. G. Douglas

This study measures antibiotic concentrations in sinonasal secretions, tissues, and serum after oral therapy in CRS patients, finding lower mucosal penetration and no significant clinical benefit except for slightly higher GSRS scores in the roxithromycin group.

bioRxiv · Jun 17, 2020 · PreprintPharmacology & Toxicology