Author

C.-t. Hung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

B. Lee· 5 shared C. S. Stevens· 2 shared J. A. Duty· 2 shared L. Brambilla· 2 shared S. Ikegame· 2 shared S. Kowdle· 2 shared A. Gowlikar· 1 shared A. Sookdeo· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

B. Lee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies

J. Beaulaurier, L. Ly, J. A. Duty, C. Tyer, C. Stevens, C.-t. Hung, A. Sookdeo, A. W. Drong, S. Kowdle, D. J. Turner, S. Juul, S. Hickey, B. Lee

This study uses single-cell transcriptomics and germline haplotype assembly to discover antibodies from human blood post-MMR vaccination, showing neutralization of measles virus.

bioRxiv · Mar 26, 2024 · PreprintImmunology

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

K. E. Atanasoff, L. Brambilla, D. C. Adelsberg, S. S. Kowdle, C. S. Stevens, C.-t. Hung, Y. Fu, R. Lim, L. Tran, R. Allen, J. A. Duty, G. Bajic, B. Lee, D. Tortorella

This paper characterizes the binding specificity and epitope of a broadly neutralizing anti-SARS-CoV-2 Spike RBD antibody using mAb-resistant virions and cryo-EM structural analysis.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

S. Ikegame, T. Hashiguchi, C.-t. Hung, K. Dobrindt, K. Brennand, M. Takeda, B. Lee

The paper identifies hyperfusogenic measles virus F protein mutants associated with neuropathogenic phenotypes through a saturating mutagenesis screen.

bioRxiv · Dec 22, 2020Microbiology

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

C. S. Stevens, K. Y. Oguntuyo, S. Kowdle, A. Gowlikar, M. N. Siddiquey, J. A. Acklin, G. Haas, R. M. Schilke, M. D. Woolard, H. Zhang, L. Brambilla, S. Ikegame, C.-t. Hung, J. K. Lim, R. W. Cross, , B. Lee

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

Antibiotic concentrations in the sinonasal secretions and tissue in CRS patients after oral therapy: a randomized trial

J. Siu, L. Klingler, Y. Wang, C.-T. Hung, S. H. Jeong, S. Smith, M. Tingle, B. Mackenzie, K. Biswas, R. G. Douglas

This study measures antibiotic concentrations in sinonasal secretions, tissues, and serum after oral therapy in CRS patients, finding lower mucosal penetration and no significant clinical benefit except for slightly higher GSRS scores in the roxithromycin group.

bioRxiv · Jun 17, 2020 · PreprintPharmacology & Toxicology

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

E. Genoyer, K. Kulej, C.-t. Hung, P. A. Thibault, K. Azarm, T. Takimoto, B. A. Garcia, B. Lee, S. Lakdawala, M. D. Weitzman, C. B. Lopez

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology