Author

M. Troll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. Grallert· 2 shared L. Ramakrishnan· 2 shared P. H. Edelstein· 2 shared A. Forman· 1 shared A. Franke· 1 shared A. Fritsche· 1 shared A. Hansen· 1 shared A. J. Pagan· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

H. Grallert

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gaucher Disease Protects Against Tuberculosis

J. Fan, V. L. Halre, L. T. Lelieveld, L. J. Whitworth, E. M. Busch-Nentwich, M. Troll, P. H. Edelstein, T. M. Cox, F. J. Roca, J. M. F. G. Aerts, L. Ramakrishnan

This paper shows that the GBA1 N370S mutation, common in Ashkenazi Jews, protects against tuberculosis by enhancing macrophage microbicidal activity through glucosylsphingosine.

bioRxiv · Oct 16, 2022Microbiology

Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

L. Whitworth, R. Troll, A. J. Pagan, F. Roca, P. H. Edelstein, M. Troll, D. Tobin, N. H. Phu, N. D. Bang, G. Thwaites, N. T. Thuong Thuong, R. Sewell, L. Ramakrishnan

The paper examines how pre-treatment CSF cytokine levels influence survival in dexamethasone-treated tuberculous meningitis, finding higher cytokine levels correlate with better survival.

bioRxiv · Nov 23, 2020Immunology

Arrhythmic gut microbiome signatures for risk profiling of Type-2 Diabetes

S. Reitmeier, S. Kiessling, T. Clavel, M. List, E. L. Almeida, T. G. Ghosh, K. Neuhaus, M. Troll, H. Grallert, W. Rathmann, B. Linkohr, A. Franke, C. I. Le Roy, J. Bell, T. Spector, , D. Haller

The paper identifies arrhythmic gut microbiome signatures associated with Type-2 Diabetes risk and validates them in a separate cohort.

bioRxiv · Dec 27, 2019Microbiology

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert Wilhelm Koivula, Petra J. M. Elders, Simone P. Rauh, Angus G. Jones, Reinhard Walter Holl, Julia Stingl, Paul W. Franks, Mark I. McCarthy, Leen M. ‘t Hart, Ewan R. Pearson, , A. Forman

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.

Diabetes Care · Mar 18, 2019Peer-reviewedGenetics