MicrobiologybioRxiv
Gaucher Disease Protects Against Tuberculosis
J. Fan, V. L. Halre, L. T. Lelieveld…·L. Ramakrishnan
This paper shows that the GBA1 N370S mutation, common in Ashkenazi Jews, protects against tuberculosis by enhancing macrophage microbicidal activity through glucosylsphingosine.
DOI 10.1073/pnas.2217673120