J. Fan

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

Macrophages undergo functionally significant reprogramming of nucleotide metabolism upon classical activation

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

Temporal dynamics and genomic programming of plasma cell fates

This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenasecomplex and impact muscle cell metabolism

This study shows reactive nitrogen species inhibit BCKDC by modifying its E2 subunit lipoic arm, leading to reduced BCAA oxidation and altered energy metabolism in muscle cells.

Coenzyme Q4 is a functional substitute for coenzyme Q10 and can be targeted to the mitochondria

The paper shows CoQ4 can substitute for CoQ10 in cells and describes mitochondrial-targeting compounds that deliver CoQ4.

Single-molecule digital sizing of proteins in solution

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos

This study identifies histone H1.2 as the carrier for PAR translocation from the nucleus to the cytosol, initiating parthanatos, and shows its role in neuronal injury models.

Spatial redundancy transformer for self-supervised fluorescence image denoising

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

Climate, host and geography shape insect and fungal communities of trees

This study identifies climate, host-related, and geographic factors shaping insect and fungal communities on trees, showing climate change could impact these communities through host range shifts and human-mediated transport.

A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

This paper introduces a method to align molecular transcriptomics data with tissue atlases using geometric and optimization techniques, enabling integration of diverse datasets into a common coordinate system.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

This study investigates BAFF's role in senescence by showing its cell-type-specific effects on SASP and growth arrest.

Gaucher Disease Protects Against Tuberculosis

This paper shows that the GBA1 N370S mutation, common in Ashkenazi Jews, protects against tuberculosis by enhancing macrophage microbicidal activity through glucosylsphingosine.

A hybrid reconstruction of the physical model with the deep-learning that improves structured illumination microscopy

This paper introduces a hybrid method combining a physical model with deep learning to improve structured illumination microscopy, achieving better artifact suppression and resolution in low SNR images.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Pathogen effector-associated nuclear-localization of RPW8.2 amplifies its expression to boost immunity in Arabidopsis

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

Innate and adaptive immune basis of mental health effect on Alzheimer's disease progression

This study investigates how mental health interventions affect Alzheimer's disease progression through immune mechanisms in transgenic mice.

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transfer

This study shows that combining TBX18 gene transfer with Tgfβ inhibition sustains biological cardiac pacing in rats beyond four weeks.

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.