Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic 'off-the-shelf' regulatory T cell therapy
O. McCallion, W. Du, V. Glaser, K. Milward, C. Franke, J. Kath, M. Valkov, M. Yang, A. Künkele, J. K. Polansky, M. Schmueck-Henneresse, H.-D. Volk, P. Reinke, D. L. Wagner, J. Hester, F. Issa
This study shows that matching or engineering HLA-I and HLA-II improves the efficacy of allogeneic regulatory T cells for immunoregulation.
bioRxiv · Aug 6, 2023 · PreprintImmunology