Author

O. McCallion

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. L. Wagner· 2 shared F. Issa· 2 shared H.-D. Volk· 2 shared J. Hester· 2 shared J. K. Polansky· 2 shared J. Kath· 2 shared M. Schmueck-Henneresse· 2 shared M. Yang· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

D. L. Wagner

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Author profile →

2 papers

Recent·Most cited

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

W. Du, F. Noyan, O. McCallion, V. Drosdek, J. Kath, V. Glaser, C. Fuster-Garcia, M. Yang, M. Stein, O. Weber, J. K. Polansky, T. Cathomen, E. Jaeckel, J. Hester, F. Issa, , D. L. Wagner

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

bioRxiv · Mar 18, 2024 · PreprintImmunology

Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic 'off-the-shelf' regulatory T cell therapy

O. McCallion, W. Du, V. Glaser, K. Milward, C. Franke, J. Kath, M. Valkov, M. Yang, A. Künkele, J. K. Polansky, M. Schmueck-Henneresse, H.-D. Volk, P. Reinke, D. L. Wagner, J. Hester, F. Issa

This study shows that matching or engineering HLA-I and HLA-II improves the efficacy of allogeneic regulatory T cells for immunoregulation.

bioRxiv · Aug 6, 2023 · PreprintImmunology