Cell BiologybioRxiv
Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
D. T. Sessions, K.-B. Kim, J. A. Kashatus…·D. F. Kashatus
This study shows that Opa1, not Drp1, is critical for maintaining ETC function and NAD+ regeneration in KRas-mutant lung adenocarcinoma, with Opa1 deletion inhibiting tumor growth.
DOI 10.1016/j.celrep.2022.111818