ImmunologybioRxiv
Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi
M. Weimershaus, C. Carvalho, E. Enee…·O. Hermine
This study identifies IRAP as a regulator of cytokine export from the Golgi in mast cells, showing its role in TNF- and IL-6 secretion and its therapeutic potential in inflammation.
DOI 10.1016/j.jaci.2023.01.014