CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion
I. F. Davidson, R. Barth, M. Zaczek, J. van der Torre, W. Tang, K. Nagasaka, R. Janissen, J. Kerssemakers, G. Wutz, C. Dekker, J.-M. Peters
The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.
bioRxiv · Sep 8, 2022 · PreprintBiophysics