R. Janissen

This study visualizes twin-supercoiled domains formed during transcription using single-molecule experiments, showing equal upstream and downstream supercoiling without requiring RNA transcript drag.

This study investigates how ParB-DNA interactions form a dynamic partition condensate for bacterial chromosome segregation using in vitro experiments and simulations.

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

This study shows that controlled spatial organization of Xylella fastidiosa cells reveals filamentation is essential for biofilm formation, driven by quorum sensing and cluster density.

The paper uses high-throughput magnetic tweezers to study E. coli RNA polymerase dynamics, identifying two long-lived backtrack pause states and showing RNA cleavage governs recovery from deep backtracks.

This study shows that condensin extrudes DNA loops in steps of up to 500 bp, driven by ATP binding, using magnetic tweezers and simulations.

This study shows that a ribonucleotide analogue induces copy-back RNA synthesis, a new mechanism to combat RNA viruses by promoting defective viral genomes.