Resource misallocation as a mediator of fitness costs in antibiotic resistance.
A. Trauner, A. Banaei-Esfahani, S. M. Gygli, P. Warmer, J. Feldmann, S. Shafieechashmi, K. Eschbach, M. Zampieri, S. Borrell, B. C. Collins, C. Beisel, R. Aebersold, S. Gagneux
The paper investigates the fitness cost of rifampicin resistance in Mycobacterium tuberculosis using transcriptomic and proteomic profiling, finding that aberrant gene expression causes the cost and that this burden can be suppressed.
bioRxiv · Nov 27, 2018 · PreprintMicrobiology