Author

S. Borrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6 Evolutionary Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Approach:statistical model· 5 Assay:whole-genome sequencing· 5 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

S. Gagneux· 11 shared C. Loiseau· 6 shared D. Brites· 5 shared M. Reinhard· 5 shared A. Trauner· 4 shared C. Beisel· 3 shared H. Cox· 3 shared J. Feldmann· 3 shared

Activity by Year

2018-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

11 shared papersMicrobiology

S. Gagneux

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

A. Arbues, S. Schmidiger, M. Reinhard, S. Borrell, S. Gagneux, D. Portevin

This study examines how different Mycobacterium tuberculosis complex lineages elicit varying granulomatous responses in vitro, linking genetic diversity to immune activation and bacterial growth.

bioRxiv · May 21, 2024Immunology

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

H. Hiza, Z. Michaela, J. Hella, A. Arbues, M. Sasamalo, S. Borrell, Z. M. Xu, A. Ross, D. Brites, J. Fellay, K. Reither, S. Gagneux, D. Portevin

The study infects macrophages from tuberculosis patients with different MTBC lineages to show that bacterial phylogenetic diversity, not local adaptation, drives variable macrophage responses.

bioRxiv · Dec 13, 2023Microbiology

HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa

E. M. Windels, E. M. Wampande, M. L. Joloba, W. H. Boom, G. A. Goig, H. Cox, J. Hella, S. Borrell, S. Gagneux, D. Brites, T. Stadler

This study uses genomic data and a Bayesian phylodynamic model to show HIV co-infection reduces Mycobacterium tuberculosis transmissibility in sub-Saharan Africa.

bioRxiv · Sep 12, 2023Microbiology

HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis

C. Loiseau, D. Brites, M. Reinhard, K. Zuercher, S. Borrell, M. Ballif, L. Fenner, H. Cox, L. K. Rutaihwa, R. J. Wilkinson, M. Yotebieng, E. J. Carter, A. Abimiku, O. Marcy, E. Gotuzzo, , S. Gagneux

The paper analyzes drug-resistant Mtb genomes from HIV coinfected and HIV negative patients, finding that HIV coinfected patients have more low fitness rpoB variants in rifampicin-resistant strains.

bioRxiv · Jul 20, 2020Evolutionary Biology

The Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis is Modulated by the Genetic Background

R. A. D. Castro, A. Ross, L. Kamwela, M. Reinhard, C. Loiseau, J. Feldmann, S. Borrell, A. Trauner, S. Gagneux

This study shows that the genetic background of Mycobacterium tuberculosis significantly affects the evolution of fluoroquinolone resistance in both in vitro experiments and clinical isolates.

bioRxiv · Jun 3, 2019Microbiology

Resource misallocation as a mediator of fitness costs in antibiotic resistance.

A. Trauner, A. Banaei-Esfahani, S. M. Gygli, P. Warmer, J. Feldmann, S. Shafieechashmi, K. Eschbach, M. Zampieri, S. Borrell, B. C. Collins, C. Beisel, R. Aebersold, S. Gagneux

The paper investigates the fitness cost of rifampicin resistance in Mycobacterium tuberculosis using transcriptomic and proteomic profiling, finding that aberrant gene expression causes the cost and that this burden can be suppressed.

bioRxiv · Nov 27, 2018 · PreprintMicrobiology

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis

J. L. Payne, F. Menardo, A. Trauner, S. Borrell, S. Gygli, C. Loiseau, S. Gagneux, A. Hall

The paper shows transition bias drives antibiotic resistance mutations in Mycobacterium tuberculosis, suggesting mutation supply, not selection, is the cause.

bioRxiv · Sep 20, 2018Evolutionary Biology

Whole genome sequencing for drug resistance profile prediction in Mycobacterium tuberculosis

S. M. Gygli, P. M. Keller, M. Ballif, N. Blöchliger, R. Hömke, M. Reinhard, C. Loiseau, C. Ritter, P. Sander, S. Borrell, J. C. Loo, A. Avihingsanon, J. Gnokoro, M. Yotebieng, M. Egger, , E. C. Böttger

This study uses whole genome sequencing to predict drug resistance profiles in M. tuberculosis isolates, achieving high sensitivity and specificity compared to phenotypic testing.

bioRxiv · Aug 28, 2018Microbiology

Reference Set of Mycobacterium tuberculosis Clinical Strains: A tool for research and product development

S. Borrell, A. Trauner, D. Brites, L. Rigouts, C. Loiseau, M. Coscolla, S. Niemann, B. De Jong, D. Yeboah-Manu, M. Kato-Maeda, J. Feldmann, M. Reinhard, C. Beisel, S. Gagneux

The paper introduces a reference set of 20 genetically characterized Mycobacterium tuberculosis clinical strains to enhance TB research by incorporating phylogenetic diversity beyond the commonly used lab strains.

bioRxiv · Aug 25, 2018Microbiology

A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex

D. Brites, C. Loiseau, F. Menardo, S. Borrell, M. B. Boniotti, R. Warren, A. Dippenaar, S. D. C. Parsons, C. Beisel, M. A. Behr, J. A. Fyfe, M. Coscolla, S. Gagneux

This study analyzes 529 MTBC genomes to reveal the phylogenetic relationships and evolutionary history of animal-adapted MTBC ecotypes, identifying four clades and suggesting host shifts and demographic factors drive host tropism.

bioRxiv · Aug 3, 2018Evolutionary Biology

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

M. Merker, M. Barbier, H. Cox, J.-P. Rasigade, S. Feuerriegel, T. A. Kohl, R. Diel, S. Borrell, S. Gagneux, V. Nikolayevskyy, S. Andres, U. Nübel, P. Supply, T. Wirth, S. Niemann

The paper investigates the evolutionary mechanisms behind multidrug-resistant tuberculosis in Central Asia, finding that compensatory mutations enhance resistance and transmission success.

bioRxiv · May 31, 2018Evolutionary Biology