C. Beisel

Cell-free expression with a quartz crystal microbalance enables rapid, dynamic, and label-free characterization of membrane-interacting proteins

The paper introduces TXTL-QCMD, a method to dynamically characterize membrane-interacting proteins without purification or labeling, revealing insights into IIMP-membrane interactions.

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in Drosophila gut during inflammation

This study shows that MprF in Lactiplantibacillus plantarum helps it survive in Drosophila gut during inflammation by reducing immune response and maintaining microbial stability.

An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between Klebsiella species

The paper adapts Cas9-based gene editing to study species-specific competition mechanisms in Klebsiella species.

Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer

This study uses long-read single-cell RNA sequencing to detect isoforms and genomic alterations in ovarian cancer, revealing novel isoforms, cell type-specific expression patterns, and gene fusions.

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancer

This study uses single-cell RNA-Seq to identify molecular states and partial EMT phenotypes in breast cancer tumours and metastases, revealing common transcription factors across patients.

Beneficial Lactiplantibacillus plantarum promote Drosophila growth by down-regulating the expression of PGRP-SC1

This study identifies PGRP-SC1 down-regulation by beneficial Lactiplantibacillus plantarum as a mechanism promoting Drosophila growth through increased microbial proliferation and metabolite production.

A statistical test for clonal exclusivity in tumour evolution

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

Spatial distribution of private gene mutations in clear cell renal cell carcinoma

The paper analyzes intra-tumour heterogeneity and subclonal mutations in clear cell renal cell carcinoma using multi-regional sequencing, finding that most tumours harbor private mutations and clonally exclusive pathway pairs.

Large-scale phylogenomics of the genus Macrostomum (Platyhelminthes) reveals cryptic diversity and novel sexual traits

This study uses phylogenomic data to reveal cryptic diversity and novel traits in the flatworm genus Macrostomum, identifying 94 potentially new species.

Dynamic changes of genomic and transcriptomic tumor diversity during melanoma progression

This study tracks genomic and transcriptomic changes in melanoma progression using a mouse model, identifying key genes and pathways involved in metastasis.

Resource misallocation as a mediator of fitness costs in antibiotic resistance.

The paper investigates the fitness cost of rifampicin resistance in Mycobacterium tuberculosis using transcriptomic and proteomic profiling, finding that aberrant gene expression causes the cost and that this burden can be suppressed.

Multiple Introductions of the Mycobacterium tuberculosis Lineage 2 Beijing into Africa over centuries

This study uses whole genome sequences to show that L2-Beijing tuberculosis strains were introduced multiple times into Africa from East and Southeast Asia over the past 300 years, likely due to hypervirulence and transmissibility.

Reference Set of Mycobacterium tuberculosis Clinical Strains: A tool for research and product development

The paper introduces a reference set of 20 genetically characterized Mycobacterium tuberculosis clinical strains to enhance TB research by incorporating phylogenetic diversity beyond the commonly used lab strains.

A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex

This study analyzes 529 MTBC genomes to reveal the phylogenetic relationships and evolutionary history of animal-adapted MTBC ecotypes, identifying four clades and suggesting host shifts and demographic factors drive host tropism.

Bacterial adaptation to diet is a key evolutionary force shaping Drosophila-Lactobacillus symbiosis

This study shows that bacterial adaptation to diet, not the host, drives the evolution of beneficial symbiosis between Drosophila and Lactobacillus.