Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection
G. R. Visweswaran, K. Vijayan, R. Chandrasekaran, O. Trakhimets, S. L. Whiteside, V. Vigdorovich, A. Yang, A. Raappana, A. Watson, W. Selman, M. Zuck, N. Dambrauskas, A. Kaushansky, D. N. Sather
This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.
bioRxiv · Sep 10, 2021 · PreprintImmunology