A. Kaushansky

Using machine learning to dissect host kinases required for Leishmania internalization and development

This study uses a kinase inhibitor screen to identify host kinases involved in Leishmania uptake and survival in macrophages, revealing both known and novel regulators.

Host kinase regulation of Plasmodium vivax dormant and replicating liver stages

This study uses kinase regression to identify host kinases regulating P. vivax liver-stage parasites, revealing variability in host dependencies across isolates that may explain field heterogeneity.

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Elucidating spatially-resolved changes in host signaling during Plasmodium liver-stage infection

This study uses digital spatial profiling to analyze host signaling changes in Plasmodium yoelii-infected hepatocytes in vivo, revealing spatial heterogeneity and immune cell responses.

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication

This study shows that dengue virus activates mTORC2 to prevent apoptosis and enhance viral replication.

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.

Plasmodium secretion induces hepatocyte lysosome exocytosis and promotes parasite entry

This study shows that Plasmodium sporozoites induce hepatocyte lysosome exocytosis through secreted factors, facilitating parasite entry and highlighting parallels with Trypanosoma cruzi infection.

Ferroptosis-like signaling facilitates a potent innate defense against Plasmodium infection

This study shows that ferroptosis-like signaling controls Plasmodium liver infection by reducing parasite survival and enhancing host cell death.