Author

R. Chandrasekaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

A. Kaushansky

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5 papers

Recent·Most cited

BiochemistrybioRxivNov 21, 2022

Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein

M. G. Alteen, J. C. Deme, C. P. Alvarez…·R. J. Harding

This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.

DOI 10.1016/j.str.2023.06.002

humanproteomics

𝕏 PostBluesky

BioengineeringbioRxivSep 14, 2022

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

S. A. Rodriguez-Aponte, N. C. Dalvie, T. Y. Wong…·J. C. Love

DOI 10.1016/j.vaccine.2022.12.062

𝕏 PostBluesky

BiophysicsbioRxivPreprintMay 27, 2022

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin Receptor

A. Ranganathan, M. M. M. Sena, R. Chandrasekaran…·M. Gromiha

This study uses molecular dynamics and free energy calculations to analyze insulin-IR interactions and identify potency determinants in natural and synthetic insulin analogs.

DOI 10.1101/2022.05.27.493461

humanstructural biology

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 10, 2021

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

G. R. Visweswaran, K. Vijayan, R. Chandrasekaran…·D. N. Sather

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

DOI 10.1101/2021.09.10.459481

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivSep 15, 2020

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium liver stage

K. Vijayan, R. Chandrasekaran, O. T. Trakhimets…·A. Kaushansky

This study shows non-neutralizing antibodies can reduce the effectiveness of neutralizing antibodies against Plasmodium CSP, impacting vaccine efficacy in malaria-exposed individuals.

DOI 10.1016/j.celrep.2021.109489

mouseproteomics

𝕏 PostBluesky