ImmunologybioRxiv
CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-B pathway
A. Armento, T. L. Schmidt, I. Sonntag…·M. Ueffing
This study shows that loss of CFH in RPE cells increases inflammation and disrupts complement regulation via the NF-κB pathway, contributing to AMD pathology.
DOI 10.3390/ijms22168727