Author

M. Ueffing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1 Biophysics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Armento· 3 shared B. Arango-Gonzalez· 3 shared E. Kilger· 3 shared S. Bolz· 3 shared S. J. Clark· 3 shared I. Sonntag· 2 shared K. Schenke-Layland· 2 shared M. Sen· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

A. Armento

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Ciliopathy-associated missense mutations in IFT140 are hypomorphic and have edgetic effects on protein interaction networks

T. Leonhard, G. D. Diwan, F. Klose, I. F. Stehle, K. Junger, M. Seda, S. Bolz, F. Woerz, R. B. Russell, K. Boldt, D. Jenkins, M. Ueffing, T. Beyer

This study investigates how missense mutations in IFT140 affect protein interactions and complex stability, revealing hypomorphic and edgetic effects in ciliopathy-related diseases.

bioRxiv · Jan 18, 2023Cell Biology

FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture model

A. Armento, A. Murali, J. Marzi, B. Arango-Gonzalez, E. Kilger, S. J. Clark, K. Schenke-Layland, C. A. Ramlogan-Steel, J. C. Steel, M. Ueffing

This study shows that loss of FH in RPE cells causes retinal degeneration in a co-culture model with porcine retinal explants, with rod cells being the first to degenerate.

bioRxiv · Jul 26, 2021Cell Biology

Pharmacological inhibition of the VCP/proteasome axis rescues photoreceptor degeneration in RHOP23H rat retinal explants

M. Sen, O. Kutsyr, B. Cao, S. Bolz, B. Arango-Gonzalez, M. Ueffing

The paper shows that inhibiting VCP/proteasome activity rescues photoreceptor degeneration in RHOP23H rat retinal explants.

bioRxiv · Jun 14, 2021Cell Biology

Self-assembled nanoparticles enable delivery of VCP inhibitor, resulting in enhanced photoreceptor protection in retinal explants

M. Sen, M. Al-Amin, E. Kickova, A. Sadeghi, J. Puranen, A. Urtti, P. Caliceti, S. Salmaso, B. Arango-Gonzalez, M. Ueffing

The paper develops nanoformulations of a VCP inhibitor to improve its solubility and delivery, showing enhanced photoreceptor protection in a retinal degeneration model.

bioRxiv · Jun 11, 2021 · PreprintPharmacology & Toxicology

CFH loss in human RPE cells leads to inflammation and complement system dysregulation via the NF-B pathway

A. Armento, T. L. Schmidt, I. Sonntag, D. Merle, M.-a. Jarboui, E. Kilger, S. J. Clark, M. Ueffing

This study shows that loss of CFH in RPE cells increases inflammation and disrupts complement regulation via the NF-κB pathway, contributing to AMD pathology.

bioRxiv · Apr 19, 2021Immunology

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

A. Armento, S. Honisch, V. Panagiotakopoulou, I. Sonntag, A. Jacob, E. Kilger, M. Deleidi, S. J. Clark, M. Ueffing

This study shows that loss of Complement Factor H in human RPE cells reduces antioxidant capacity and impairs energy metabolism, contributing to AMD pathogenesis.

bioRxiv · Jan 8, 2020Cell Biology

Allosteric structural alterations and auto-regulation of Rab5 GEF activity in Rabex5

J. Lauer, A. Cezanne, G. Guaitoli, F. Raimondi, M. Gentzel, V. Alva, M. Habeck, M. Ueffing, A. N. Lupas, C. J. Gloeckner, M. Zerial

This study reevaluates the autoinhibition mechanism of Rabex5 by analyzing structural changes and nucleotide exchange activity, revealing new regulatory roles for Ubiquitin binding domains.

bioRxiv · Feb 27, 2019 · PreprintBiophysics

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue Models

K. Achberger, C. Probst, J. Haderspeck, S. Bolz, J. Rogal, J. Chuchuy, M. Nikolova, V. Cora, L. Antkowiak, W. Haq, N. Shen, K. Schenke-Layland, M. Ueffing, S. Liebau, P. Loskill

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.

bioRxiv · Feb 18, 2019Bioengineering