Compensatory mutations potentiate constructive neutral evolution by gene duplication
P. C. Despres, A. K. Dube, J. Grenier, M.-E. Picard, R. Shi, C. R. Landry
The paper duplicates and evolves an homodimeric enzyme to show that compensatory mutations can lead to functional heteromers through subfunctionalization.
bioRxiv · Feb 12, 2024Evolutionary Biology