C. R. Landry

The paper investigates the evolution of HRR25 ohnologs after a whole-genome duplication in yeast, finding that nonfunctionalization, not subfunctionalization, is the main trend.

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

This study investigates how SH3 domains of paralogous yeast myosins evolved their binding preferences, finding that differences in interactions are not due to the SH3 domains themselves but to context-dependent factors.

This study examines how fungal lifestyles, such as pathogenicity and insect association, influence genome size and gene content in Sordariomycetes fungi.

The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.

The paper shows yeast paralogous genes are more divergent in transcription than translation, attributing this to evolutionary trade-offs and mutational bias.

The paper studies genetic and phenotypic diversity across 1,800 Saccharomyces strains, revealing insights into macroevolutionary processes and gene flow effects on traits.

The paper measures amino acid substitutions in yeast Fcy1 to show a trade-off between 5-FC resistance and enzyme function, with similar patterns in Cryptococcus neoformans.

The paper examines mutation rates and spectra in yeast hybrids, finding significant variation among crosses that is genotype-specific rather than related to parental divergence.

The paper identifies ecological signals that trigger spore activation in closely related budding yeast species, showing divergence in their response to environmental cues.

The paper investigates the fitness effects of gene duplication in budding yeast, finding that most protein complex subunits have minimal fitness impact, while large complexes are protected by reduced protein abundance.

This study examines protein-protein interactions in a yeast hybrid, finding frequent chimeric complexes with some exceptions due to parental protein incompatibilities.

The paper identifies gene-microbe interactions in co-cultures of Saccharomyces cerevisiae and Pseudomonas spp., showing that 643 genes show fitness differences, with 36% of interactions not replicable in cell-free experiments.

The paper examines how paralog dependency affects cellular robustness by analyzing gene loss-of-function in human cell lines using CRISPR-Cas9.

The paper investigates how structural pleiotropy and regulatory evolution influence the retention of heteromers formed by paralogs in budding yeast.

The paper examines de novo ORF emergence in wild yeast, finding some intergenic ORFs show gene-like characteristics despite lower translation efficiency and suggesting functional innovation potential.

The paper identifies alternative open reading frames (altORFs) that encode small proteins, showing functional cooperation with larger proteins from the same gene.