Author

P. C. Despres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. K. Dube· 3 shared C. R. Landry· 3 shared I. Gagnon-Arsenault· 2 shared A. F. C. Caballero· 1 shared A. F. Cisneros Caballero· 1 shared A. Pageau· 1 shared C. Gagne-Thivierge· 1 shared E. M. Alexander· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

A. K. Dube

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 27, 2023

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

F. D. Rouleau, A. K. Dube, I. Gagnon-Arsenault…·C. R. Landry

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

DOI 10.1101/2023.09.27.559786

humanproteomics

𝕏 PostBluesky

Evolutionary BiologybioRxivJun 7, 2022

Epistasis between promoter activity and coding mutations shapes gene evolvability

A. F. C. Caballero, I. Gagnon-Arsenault, A. K. Dube…·C. R. Landry

The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.

DOI 10.1126/sciadv.add9109

protein structureexperimental assay

𝕏 PostBluesky

Evolutionary BiologybioRxivNov 29, 2021

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient use

P. C. Despres, A. F. Cisneros Caballero, E. M. Alexander…·C. R. Landry

The paper measures amino acid substitutions in yeast Fcy1 to show a trade-off between 5-FC resistance and enzyme function, with similar patterns in Cryptococcus neoformans.

DOI 10.1038/s41559-022-01846-4

yeastfungi (other)

𝕏 PostBluesky