Cancer BiologybioRxivPreprint
CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling
V. Rubino, M. Hueppi, S. Hoepner…·C. Riether
This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.