L. Taylor

A male-essential microRNA is key for avian sex chromosome dosage compensation

This study identifies miR-2954 as a male-essential microRNA critical for avian sex chromosome dosage compensation, showing its role in balancing gene expression in males and females.

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

This study shows that SARS-CoV-2 ORF8 protein modulates lung inflammation and disease severity in mice by affecting macrophage infiltration and function.

CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.

Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism

This paper identifies a mutation in α-isopropylmalate synthase that enables Mycobacterium abscessus to resist norvaline and epetraborole by upregulating leucine biosynthesis.

A framework for linking hemispheric, full annual cycle prioritizations to local conservation actions for migratory birds

This paper presents a framework to connect hemispheric migratory bird conservation priorities with local actions, using examples from North and South Carolina and Colombia.

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness

This study shows that periostin promotes ovarian cancer recurrence by enhancing cancer stemness and chemoresistance through TME interactions.

Where, who, and what counts under area-based conservation targets: A framework for identifying opportunities that benefit biodiversity, climate mitigation, and human communities

This paper identifies conservation opportunities in the US that benefit biodiversity, climate mitigation, and human communities by aligning bird habitats, carbon stocks, and human well-being.

SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis

This study investigates how non-Spike mutations in SARS-CoV-2 variants affect pathogenesis and transmission, revealing that accessory gene mutations can lead to attenuating phenotypes.

Landscape change and alien invasions drive shifts in native lady beetle communities over a century

The paper uses museum records to analyze changes in native lady beetle communities over 12 decades, finding species-specific declines linked to alien invasions and landscape change.

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

The paper shows that combining epetraborole with norvaline enhances efficacy against Mycobacterium abscessus in a murine model.

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

The paper identifies a c-Rel and USP1 dependent pathway that regulates CHK1 inhibitor resistance in lymphoma cells.

Lineage Functional Types (LFTs): Characterizing functional diversity to enhance the representation of ecological behavior in Earth System Models

The paper develops lineage-based functional types (LFTs) to improve Earth System Models by incorporating phylogenetic relatedness and trait variation in grasses.

North American Birds Require Mitigation and Adaptation to Reduce Vulnerability to Climate Change

This study assesses the vulnerability of 604 North American bird species to climate change under different warming scenarios and finds that mitigation is needed to reduce vulnerability.

Risk to North American Birds from Climate Change-Related Threats

This study assesses climate change risks to 544 North American bird species under two warming scenarios, finding higher risk with unmitigated warming and significant impacts from extreme weather events.

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

This study identifies a specific RSV genomic sequence that regulates the generation of copy-back defective viral genomes, showing that cbDVG formation is not random and can be manipulated.