Author

M.-T. Wei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

C. P. Brangwynne· 3 shared L. Zhu· 2 shared D. Bracha· 1 shared D. M. Mitrea· 1 shared D. W. Sanders· 1 shared J. A. Riback· 1 shared J. E. Toettcher· 1 shared M. C. Ferrolino· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

C. P. Brangwynne

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3 papers

Recent·Most cited

Composition dependent phase separation underlies directional flux through the nucleolus

J. A. Riback, L. Zhu, M. C. Ferrolino, M. Tolbert, D. M. Mitrea, D. W. Sanders, M.-T. Wei, R. W. Kriwacki, C. P. Brangwynne

This study shows that heterotypic interactions drive nucleolar phase separation without a fixed saturation concentration, revealing a thermodynamic framework for condensate composition and function.

bioRxiv · Oct 22, 2019Biophysics

Nucleated transcriptional condensates amplify gene expression

M.-T. Wei, Y.-C. Chang, S. F. Shimobayashi, Y. Shin, C. P. Brangwynne

This study shows that TAF15 phase separation is enhanced by interactions with RNA Pol II CTD, lowering the energetic barrier for condensate formation and amplifying gene expression.

bioRxiv · Aug 21, 2019Biophysics

Mapping local and global liquid-liquid phase behavior in living cells using light-activated multivalent seeds

D. Bracha, M. T. Walls, M.-T. Wei, L. Zhu, M. Kurian, J. E. Toettcher, C. P. Brangwynne

This study maps intracellular phase separation behavior using an optogenetic system, showing localized phase separation can occur through diffusive capture of protein ligands.

bioRxiv · Mar 16, 2018Biophysics