Y. Shin

Context-Aware Deep Learning Enables High-Efficacy Localization of High Concentration Microbubbles for Super-Resolution Ultrasound Localization Microscopy

This paper introduces LOCA-ULM, a deep learning method for ultrasound localization microscopy that improves microbubble detection and localization accuracy in vivo and in silico.

Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron variants

This study evaluates the antiviral efficacy of remdesivir, molnupiravir, and nirmatrelvir against newly emerged SARS-CoV-2 Omicron subvariants and finds they retain antiviral activity.

Contrast-free Super-resolution Doppler (CS Doppler) based on Deep Generative Neural Networks

This paper introduces CS Doppler, a contrast-free super-resolution Doppler technique using deep generative networks, achieving improved spatial resolution and real-time imaging in vivo.

Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor

The paper identifies a novel HASPIN inhibitor, LJ4827, and shows its synergistic effect with PLK1 inhibitor BI2536 in lung cancer treatment.

High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer

This study evaluates high-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple-negative breast cancer, showing improved therapeutic outcomes and immune response.

Korean endemic species no more: on the occurrence of Pelophylax chosenicus in China

The paper surveys the distribution of Pelophylax chosenicus across Korea and China, finding it widespread in wetlands with a northernmost population in China.

Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries

This study shows that flow-conditioning improves endothelial function and prevents vessel regression in engineered human capillaries.

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

The paper identifies a conserved Arg residue in multi-subunit RNA polymerases that uses a two-pronged strategy to select against 2’dNTPs by interacting with both the 2’OH and 3’OH groups.

Nucleated transcriptional condensates amplify gene expression

This study shows that TAF15 phase separation is enhanced by interactions with RNA Pol II CTD, lowering the energetic barrier for condensate formation and amplifying gene expression.