SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation
D. W. Sanders, C. C. Jumper, P. J. Ackerman, D. Bracha, A. Donlic, H. Kim, D. Kenney, I. Castello-Serrano, S. Suzuki, T. Tamura, A. H. Tavares, M. Saeed, A. S. Holehouse, A. Ploss, I. Levental, , C. P. Brangwynne
This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.
bioRxiv · Dec 14, 2020Cell Biology