Author

Madeline Laramee

New York State Psychiatric Institute

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Neuroscience· 1

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Approach:experimental assay· 1

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Alice L. RodrigueziD· 1 shared Colleen Marie NiswenderiD· 1 shared Jonathan A. JavitchiD· 1 shared Justin B. SteinfeldiD· 1 shared Paul K. Spearing· 1 shared Wesley B. AsheriD· 1 shared Xia LeiiD· 1 shared Xin LiniD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperNeuroscience

Alice L. RodriguezORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintMay 22, 2026

Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu1/5 Heterodimers

Justin B. Steinfeld, Xia Lei, Madeline Laramee…·Jonathan A. Javitch

The paper shows that signaling in mGlu1/5 heterodimers is dominated by the mGlu protomer, leading to emergent signaling and allosteric inversion, with implications for drug design.

DOI 10.64898/2026.05.20.726619

experimental assay

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