Jonathan A. Javitch

This study shows that early developmental fluoxetine exposure impairs adult motivation in mice, which can be reversed by nucleus accumbens mu opioid receptor antagonism.

This study shows CVN636 enhances orthosteric agonist responses at mGlu7 homodimers but not heterodimers.

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

This study examines how ADGRL3 knockout affects dopamine release in mice, finding increased ex vivo release and reduced in vivo task-induced signals in the nucleus accumbens.

The paper develops a transformer-based autoencoder framework to analyze conformational landscapes of β-arrestin 1 tail in basal and active states, revealing modular organization and state-dependent dynamics.

The paper shows that signaling in mGlu1/5 heterodimers is dominated by the mGlu protomer, leading to emergent signaling and allosteric inversion, with implications for drug design.

The paper shows that direct tensile force on Adgrl3's N-terminus activates G protein recruitment in living cells, requiring a functional tethered agonist and force-driven conformational changes.

This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.

The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.

This study shows that chronic MOR blockade or habenular MOR knockout increases anxiety and pain sensitivity in mice.

This study uses molecular dynamics simulations to investigate the conformational changes in β-arrestin 1 during activation by the vasopressin receptor-2.

This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.

This study shows that deleting D2 receptors from striatal cholinergic interneurons impairs action sequence learning, while viral replacement rescues this behavior.

This study shows that Lphn2's role in axon targeting depends on context-specific G protein coupling and autoproteolytic cleavage.

This study shows that tianeptine, but not fluoxetine, reduces avoidant behavior in mice prenatally exposed to fluoxetine, suggesting it may be a better treatment for altered serotonergic systems.

This study shows that dopamine D2 receptors in cholinergic interneurons modulate the pause in neuronal activity and impair inhibitory learning in a Go/No-Go task.

This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.

The paper shows disrupting D2-NMDA receptor heteromerization blocks cocaine's rewarding effects without affecting natural reward processing in mice and humans.

The paper demonstrates D2R-A2AR proximity in human ventral striatum using PLA and a Bayesian classifier, supporting their potential formation of heteromers.

This study shows that the lipid environment affects dopamine transporter function, specifically influencing amphetamine response in mice.

The paper identifies distinct antagonist-bound inactive states in dopamine D2 and D3 receptors, showing conformational diversity with implications for drug discovery.