Author

Madison C. Garibotti

York University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

Christopher G. R. PerryiD· 4 shared Jeremy A. SimpsoniD· 4 shared Luca J. DelfinisiD· 4 shared Shivam Gandhi· 4 shared Aditya N. BrahmbhattiD· 3 shared Brooke A. Morris· 3 shared Jim PetrikiD· 3 shared Leslie M. OgilvieiD· 3 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Christopher G. R. PerryORCID

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4 papers

Recent·Most cited

The mitochondrial-targeted antioxidant SkQ1 prevents mitochondrial-linked apoptosis but not necroptosis or skeletal muscle atrophy in ovarian cancer

Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih Ahmad Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie M. Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

The Journal of Physiology · Nov 2, 2025Peer-reviewedPhysiology

Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice

Luca J. Delfinis, Shahrzad Khajehzadehshoushtar, Luke D. Flewwelling, Nathaniel J. Andrews, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie M. Ogilvie, Stavroula Tsitkanou, Jeremy A. Simpson, Nicholas Perry Greene, , Christopher G. R. Perry

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

Molecular Metabolism · Jul 17, 2025Peer-reviewedPhysiology

Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy

Shivam Gandhi, Luca J. Delfinis, Parashar D Bhatt, Madison C. Garibotti, Catherine A. Bellissimo, Amireza N. Goli, Brooke A. Morris, Aditya N. Brahmbhatt, Simona Yakobov-Shimonov, Fasih Ahmad Rahman, Joe Quadrilatero, Jeremy A. Simpson, Gary Sweeney, Ali A. Abdul Sater, Peter H. Backx, , Christopher G. R. Perry

This study shows adiponectin receptor agonism prevents right ventricular fibrosis and inflammation in a mouse model of Duchenne muscular dystrophy.

Molecular Metabolism · Jun 7, 2025Peer-reviewedPhysiology

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

Luca J. Delfinis, Leslie M. Ogilvie, Shahrzad Khajehzadehshoushtar, Shivam Gandhi, Madison C. Garibotti, Arshdeep K. Thuhan, Kathy Matuszewska, Madison Pereira, Ronald G. Jones, Arthur J. Cheng, Thomas James Hawke, Nicholas Perry Greene, Kevin A. Murach, Jeremy A. Simpson, Jim Petrik, Christopher G. R. Perry

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

Molecular Metabolism · Jun 24, 2024Peer-reviewedPhysiology