Jeremy A. Simpson

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

The paper shows that browning of pericardial adipose tissue via beta3-adrenergic signaling improves cardiac function in obesity.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This study shows adiponectin receptor agonism prevents right ventricular fibrosis and inflammation in a mouse model of Duchenne muscular dystrophy.

This paper introduces ROSLT, a Raspberry-Pi-based cyclometer for tracking mouse voluntary wheel running, showing it provides more accurate and consistent measurements than VDO M2.1 over time.

The paper shows Yap signaling in cardiomyocytes is sensitive to L-isoleucine and regulates Ctgf expression, influencing myocardial adaptation after injury.

The paper identifies associations between EPO SNPs and anemia, dyslipidemia, and hypertension in cardiovascular disease patients using genotyping and clinical outcome analysis.

This paper investigates how mitochondrial bioenergetics are affected in D2.mdx mice and shows that SBT-20 can improve creatine-dependent bioenergetics by reducing oxidative stress.

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.