Jim Petrik

This study shows that prenatal cannabis smoke exposure in mice reduces placental size and function and affects fetal brain growth.

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This study shows that HER2-driven mammary tumors have reduced mitochondrial content but increased respiration, suggesting HER2 signaling enhances mitochondrial bioenergetics independently of mitochondrial content.

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

This study shows that high-fat diet during pregnancy alters maternal gut microbiota and barrier function, leading to placental hypoxia and fetal gut developmental issues.