Leslie M. Ogilvie

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.