Cell BiologybioRxiv
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
Ashley P Ng, Maria Kauppi, Donald Metcalf…·Warren S Alexander
This study shows Mpl expression on megakaryocytes and platelets is not needed for platelet production but is essential to prevent myeloproliferation by controlling TPO availability.
DOI 10.1073/pnas.1404354111