Matthew William Kellinger

Cytos MPS integrates CRISPR guide identity, morphology, transcriptomics, and protein data to reveal multimodal phenotypes from perturbations.

The paper introduces a platform that directly sequences 3'UTRs and guide RNAs in fixed cells alongside protein abundance and morphology, enabling CRISPR screening in lung cancer cells.

The paper measures RNA, protein, and morphology in NSCLC cells treated with TKIs to identify resistance mechanisms and show that CDK4/6 inhibition enhances TKI efficacy.

The paper introduces a multiomics platform for high-throughput analysis of cellular responses, demonstrating its ability to capture dynamic cellular processes and drug responses in cancer cells.

The paper demonstrates achieving over 70% Q50 accuracy on the AVITI sequencer by improving sequencing quality and mitigating library preparation and analysis errors.

This paper introduces avidity sequencing, a new chemistry that improves sequencing accuracy and reduces reagent use, enabling applications like single-cell RNA-seq and whole-genome sequencing.